I. Medical history The patient was a 75-year-old male, who started to experience gradual weakness and significant wasting in June 2007. He was seen at Peking University People’s Hospital. MRI of the abdomen showed: hepatic S7 nodular foci, small hepatocellular carcinoma may be large. PET-CT on December 4, 2008 showed: hypodense nodules in liver S4 segment with slightly increased FDG metabolism, considering hepatocellular carcinoma. Previously suffered from primary biliary cirrhosis for 5 years. Alcohol consumption for more than 40 years. Clinical diagnosis of primary hepatocellular carcinoma. Jia Liqun, Department of Integrative Medical Oncology, China-Japan Friendship Hospital, underwent hepatic artery embolization chemotherapy (chemotherapy drug: mitomycin 30ml, epi-amycin 20ml and iodine oil 5ml emulsion) for S4 segment of liver tumor in Peking University First Hospital on Jan. 6, 2009, and he underwent hepatic artery embolization chemotherapy (drug: THP 20ml and iodine oil 10ml suspension, hydroxycamptothecin 10ml) again on June 9. ) and radiofrequency ablation of the right hepatic lesion (power 35W, 45W, 50W, treatment time 40 minutes). Liver function: ALT 102IU/ml, AST 80IU/ml, GGT 97IU/ml. abdominal ultrasound showed that a heterogeneous echogenic mass with a size of about 3.7×2.8cm was seen in the left inner lobe of the liver, and an irregular fluid area was seen within it. The abdominal MRI showed several transient enhancing nodules in the left lobe of the liver and the upper and lower right lobes of the liver, with a significant increase in the number of small nodules compared with the old film and an increase in the volume of some of them. Combined with the results of the review, it was considered that the nodules of hepatocellular carcinoma had increased and the cancer had progressed. It is not suitable for re-intervention and systemic treatment with TCM or biologically targeted drugs is recommended. In July 2007, he started treatment at the outpatient clinic of the Department of Traditional Chinese Medicine and Oncology of China-Japan Friendship Hospital. At the time of consultation, he had a dark complexion, obvious weakness, a dull tongue, thick and greasy coating, and a stringent pulse. He was diagnosed with hepatic stagnation, which is caused by Qi deficiency and blood stasis. The treatment was to nourish the liver and strengthen the spleen, and to promote the circulation of stagnation. In combination with the treatment of three worms powder (under development). In October (after taking Chinese medicine for 4 months), he was re-examined: fatigue reduced, weight increased by about 3kg, red tongue, thin yellow fur, string pulse. Tumor markers: AFP 7.05ng/ml, CEA 5.36ng/ml. liver function: ALT 64IU/L, AST 48IU/L, GGT 99IU/L. abdominal MRI showed: cirrhosis, portal hypertension, small amount of ascites. Hcc in the junction area of liver S4 and S2 changed after treatment, and the change was not obvious than before. Hepatic S8 and S4 subperitoneal abnormal enhancing changes, with insignificant changes from the July 31 film. Small intrahepatic nodules, significantly reduced and smaller than the July 31 film. After taking the front, he took three worms powder for 2 months. In December (6 months after taking Chinese medicine): no obvious fatigue and other discomfort, weight stable, red tongue, thin white coating, smooth pulse. Tumor markers: AFP 2.74ng/ml, CEA 5.29ng/ml. liver function: ALT 84IU/L, AST 55IU/L, GGT 105IU/L. abdominal ultrasound showed: occupying lesion in the left lobe of liver (size about 2.9×2.6cm), after intervention; cirrhosis; calcified foci in the right lobe of liver; chronic cholecystitis. Abdominal enhancement CT showed: liver shrinkage, disproportion between the left and right lobes, multiple nodular changes in the parenchyma, uneven surface of the liver, irregular hypodense foci in the junction area of liver S4 and S2, iodine oil precipitation was seen in the area, the size was about 3.6×3.3cm, the boundary was clear, scattered dotted high-density foci were seen in the liver parenchyma, the rest did not see abnormal enhancement, thickening of the hepatic portal vein, the internal meridian was about 1.5cm, the side of the gastric lesser curvature Multiple tortuous vessels could be seen. Following the administration of the front, with the administration of three worms powder. The results of pre- and post-treatment examinations showed that AFP gradually decreased from 815 ng/ml to 2.74 ng/ml, transaminases decreased to normal level, and imaging examinations showed that intrahepatic nodules decreased significantly and became smaller. According to WHO solid tumor efficacy evaluation, the efficacy of Chinese herbal medicine before and after treatment can be evaluated as PR. III. CONCLUSION The efficacy of Chinese herbal medicine in reducing alpha-fetoprotein (AFP) in primary hepatocellular carcinoma patients is remarkable. This formula has obvious hepatoprotective effect and can improve patients’ quality of life. This formula can inhibit the progression of hepatocellular carcinoma lesions and has significant efficacy on hepatic sclerosis cancer nodules.