Neonatal sepsis is usually fatal in a few days, usually refers to the danger period of the disease, the danger period of neonatal sepsis is about 7 days to 14 days, because of the influence of the autoimmune status as well as the source of the infection, so there are differences in the danger period. Neonatal sepsis usually develops around 7 days after birth if it is of early onset, this is mainly dominated by E. coli gram-negative organisms and it has an acute onset, the danger period is usually around the very first 7 days. If sepsis occurs in newborns and appears after 7 days of life, it may be a septicemia infection caused during or after birth, and this may have other accompanying symptoms, such as umbilical cord infection, pneumonia, etc., and the danger period for this is about 7 to 14 days after birth. Parents need to go to the hospital in time to conduct relevant examinations when they find that their newborns have obvious loss of appetite, vomiting and overflow of milk, irritability, rising body temperature, etc., to clarify the cause of the disease and then actively treat the symptoms.