Neonatal sepsis (neonatalsepticemia) refers to a systemic infection caused by the invasion of bacteria into the bloodstream during the neonatal period, where they multiply and produce toxins, and sometimes produce migrating foci in the body. It is still a very important disease in the neonatal period, and its incidence is about 1‰-10‰ of live births, with a higher incidence in premature infants. Bacteremia (bacterimia) refers to the rapid clearance of bacteria after invasion into the body’s circulation, without toxemia and without the occurrence of any symptoms. Prevention of neonatal sepsis should pay attention to maternal health care: 1, prevention of neonatal sepsis should pay attention to perinatal health care to actively prevent maternal infection to prevent fetal infection in utero; 2, in the process of delivery should be strictly enforced aseptic operation of the delivery room environment resuscitation equipment resuscitation equipment, etc. should be strictly disinfected; 3, early broken water course is too long intrauterine asphyxia of newborns after birth should be prophylactic treatment; 4, do neonatal care Work should pay special attention to protect the skin mucous membrane umbilicus from infection or injury and should strictly implement the disinfection and isolation system. Also pay attention to observe the newborn’s face, sucking milk, mental status and temperature changes to keep the oral umbilical skin and mucous membrane clean if there is an infectious lesion should be dealt with in a timely manner. In addition, pay attention to the following aspects of prevention: 1, pay attention to perinatal health care, actively prevent and control maternal infection, to prevent fetal infection in utero; the best in the hospital for scientific delivery; health care workers in the delivery process to strictly implement aseptic operation, pay special attention to the disinfection and protection of the umbilical cord. 2.For newborns with early water breakage, too long labor, or intrauterine asphyxia, preventive treatment should be given after birth. 3, usually when caring for newborns, special attention should be paid to protect the newborn’s skin, mucous membranes and umbilicus from infection or injury, and the disinfection and isolation system should be strictly enforced. 4, newborns with secretions in the umbilical fossa, or small pus spots on the skin, should be painted with purple potion, and when there is a lot of pus in the umbilical fossa, you can apply some alcohol or sprinkle some anti-inflammatory powder. 5, parents should never use unsterilized needles to prick the newborn “horse teeth”, “mantis mouth”, and do not casually squeeze the newborn’s breast. 6, the mother has abscesses, pneumonia and other bacterial infections, to temporarily stop breastfeeding, milk can be boiled out and then fed, or directly with milk instead. 7. If there are no special circumstances, breastfeeding is advocated for newborns because breast milk contains growth factors and antibodies that help to strengthen the newborn’s ability to fight diseases.