Neonatal sepsis is mainly a bacterial infection: 1. Antimicrobial therapy, culturing different bacteria and giving different treatments. For example, Gram-positive bacteria, often choose treatment with benzocillin, vancomycin, teicoplanin, and Sever. In the case of gram-negative bacteria, they are often treated with third-generation cephalosporin or ampicillin antibiotics; 2. Supportive therapy, when sepsis is present, nutritional support is given to maintain the water-electrolyte balance and correct the disturbance of his acid-base balance; 3. Supportive therapy, including neutrophil infusion, intravenous gammaglobulin infusion, clotting factors and other supportive therapy. The treatment of neonatal sepsis mainly includes specific treatment and symptomatic supportive treatment.