The risk period of neonatal sepsis is related to the severity of the disease and the timeliness of treatment, but if treated effectively and promptly, most children’s infections are quickly controlled and thus out of danger. Neonatal sepsis is a systemic infection caused by pathogenic bacteria that invade the bloodstream through various routes and grow and multiply in the body, producing toxins. The common cause of neonatal sepsis is soft tissue infection, which generally lacks typical clinical manifestations. The disease is critical and progresses rapidly. If timely anti-infective treatment is taken against the causative agent in the early stage of the disease, as well as appropriate symptomatic supportive treatment, the condition can gradually improve and recover in 2-4 weeks. If the treatment is not timely or appropriate, the disease progresses rapidly and the child can die in about 3 days. Therefore, if newborns develop skin infections or lung infections, they should not be delayed and should be sent to the pediatric department for treatment in a timely manner.