Neonatal sepsis, if treated in time, heals relatively well and does not cause death. If it reaches an advanced stage, even to the point of infectious shock, the mortality rate is higher and survival will not exceed three days, also depending on the child’s specific situation. Neonatal sepsis is caused by a bacterial infection with positive blood culture results and most of the leukocytes, calcitonin and C-reactive protein are significantly elevated. Empirical anti-infective therapy is administered until the blood culture results are available. After the blood culture results are available, anti-infective treatment is administered based on the results of the blood culture. Children with neonatal sepsis need to be perfected for lumbar puncture because they have a poorly developed blood-brain barrier, poor resistance, and the possibility of septic meningitis.