The early symptoms of neonatal sepsis vary. The child may have fever or temperature not rising, poor response, not eating milk, reduced crying, reduced activity, jaundice receding and reappearing, petechiae and petechiae on the skin mucosa, and these conditions should be considered as neonatal sepsis. Neonatal sepsis must be treated promptly because the blood-brain barrier of newborns is not well developed, and sepsis can easily be combined with neonatal septic meningitis, which can leave serious sequelae. Therefore, it is important to seek medical attention in a timely manner, improve blood routine, blood culture and other tests, perform lumbar puncture if necessary, apply antibiotics early empirically, and wait for the blood culture results to come out, then further target treatment according to the results of the blood culture.