The duration of neonatal sepsis varies greatly depending on the strength of the child, the virulence of the causative bacteria, and the treatment, and cannot be generalized. Neonatal sepsis is a condition in which pathogenic bacteria invade the bloodstream during the neonatal period, multiply and produce toxins, resulting in a variety of clinical manifestations, such as depression, not eating, not crying, not moving, and even causing infectious shock and multiple organ insufficiency syndrome. Most children with neonatal sepsis improve after active anti-infective treatment and symptomatic support therapy, and if treated properly, the condition can be effectively controlled and gradually recovered in 2-4 weeks, but some children with sepsis have a poor prognosis. In addition, neonatal sepsis is a serious condition with a poor prognosis, and attention should be paid to disease prevention to avoid bacterial infections leading to sepsis.