Patients with bilateral symmetrical swelling of the arms and hands, and without pain, often have diseases of the internal organs, such as liver, kidney, heart and thyroid diseases, which are capable of causing this phenomenon. Liver diseases that can cause swelling are liver cirrhosis and liver failure; kidneys can cause such clinical manifestations, mainly nephritis, nephrotic syndrome, renal failure, uremia, etc.; heart failure can also cause swelling; thyroid diseases, especially hypothyroidism, can cause swelling of the limbs. If the patient has unilateral arm and hand swelling, it may be a thrombosis of a vein; if it is accompanied by pain, it is often a trauma or an inflammatory reaction.