When you wake up in the morning with swollen hands, you have to distinguish whether the swelling is unilateral or bilateral, whether it is localized or comprehensive. If the swelling is unilateral and localized, it may be a mosquito bite. If it is a mosquito bite, the swelling may be accompanied by an itchy sensation or a red sensation. After ruling out mosquito bites unilateral hand swelling may occur in some people, especially the elderly, with unilateral limb thrombosis, and although the incidence is low, this aspect needs to be considered if it occurs. Bilateral hand swelling may be caused by systemic systemic diseases, such as kidney disease, liver disease, rheumatic system disease, etc. Swelling may be accompanied by different symptoms in different diseases, such as swelling in rheumatic system diseases often accompanied by a feeling of stiffness in the fingers, which is relieved by activity. Swollen fingers from kidney disease are often accompanied by swelling of the eyelids bilaterally and increased foam in the urine. Swollen fingers from heart disease are often accompanied by inability to lie down at night and other symptoms such as heart failure.