Swelling of the hands after walking can be divided into two cases: one, caused by physiological reasons; two, caused by pathological reasons. Physiological causes are mainly caused by blood congestion in the hands during walking, which increases the capillary static pressure and affects the return flow of blood and swelling. In this case, if the swelling disappears after rest, no special treatment is needed and it is caused by physiological reasons. Pathological conditions are mostly seen in cases of nephritis, nephrotic syndrome, right heart failure, liver cirrhosis, hyperthyroidism, hypothyroidism, malnutrition, connective tissue diseases, etc. It is recommended to actively go to the hospital to check blood routine, urine routine, liver function, thyroid function, cardiac function, cardiac ultrasound, etc. If there are any problems, it is recommended to actively go to the corresponding department to deal with them and carry out symptomatic treatment to prevent irreversible consequences caused by delaying the disease.