The cause of swollen hands after waking up in the morning can be diseases of the renal system, mainly acute nephritis, chronic nephritis, acute interstitial nephritis, chronic interstitial nephritis, acute progressive nephritis and so on. It can also be secondary to diseases of the renal system, mainly including diabetic nephropathy, lupus nephritis, hepatitis B-related nephropathy, etc. It is also necessary to exclude the possibility of swollen hands caused by other diseases, mainly including edema caused by hypothyroidism drugs, edema caused by allergies, cardiac insufficiency, liver insufficiency, etc. If you have swollen hands in the morning, it is recommended to consult a regular hospital to improve urine routine, 24h urine protein quantification, blood biochemistry, coagulation system and other tests to clarify the diagnosis and give active and reasonable treatment.