Morning hand swelling is generally divided into physiological changes and pathological changes. Physiological changes are common in older people, and due to loose subcutaneous tissues, if the hand is in a low-hanging position during sleep, swelling is likely to occur during longer rest periods. There are also some people who may unintentionally compress their hands or upper limbs during sleep, causing impaired reflux and resulting in swelling of the hands when they wake up in the morning, a condition that generally decreases with position or time. In the second case, screening for rheumatic diseases is required to determine the presence of hand swelling caused by autoimmune diseases.