Many patients with uveitis are associated with systemic autoimmune diseases. Common systemic immune diseases that uveitis may reflect include ankylosing spondylitis, psoriasis, Reiter syndrome, inflammatory bowel disease, juvenile chronic arthritis, tubulointerstitial nephritis, nodular disease, systemic lupus erythematosus, giant cell arteritis, Wegener’s granulomatosis, multiple sclerosis, and recurrent polychondritis, with ankylosing spondylitis being the most common. Uveitis with ankylosing spondylitis accounts for 13% of all patients with uveitis in our clinic and is the most common type of uveitis. Ankylosing spondylitis occurs most often in young and middle-aged males, with uveitis occurring in about 20-30% of them. The most common systemic manifestation of this disease is lumbosacral pain, which mostly occurs before the age of 40. The pain may radiate to the iliac crest and posterior thighs and is often evident in the morning after waking up. Patients also often have morning stiffness in the lower back that decreases or disappears with activity. These symptoms are particularly likely to be misdiagnosed as a prolapsed lumbar disc. The lesion can also involve other peripheral joints throughout the body, and continued progression can lead to spinal ankylosis and deformity. X-rays and CT examinations of the sacroiliac joints can reveal a variety of changes in the spine and sacroiliac joints. In addition, patients with ankylosing spondylitis associated with uveitis have an HLA-B27 antigen positivity rate of more than 90%. The main manifestation of uveitis associated with ankylosing spondylitis is acute anterior uveitis, or iridocyclitis. Although the vast majority of patients with uveitis occur after arthritis, many of these patients will present to the ophthalmology department for their first visit because of the occurrence of uveitis, when they are unaware that they have ankylosing spondylitis, due to the mildness of their previous lumbar symptoms or misdiagnosis of other diseases. Because early detection of ankylosing spondylitis allows for good prevention and treatment, allowing patients to maintain a better quality of life, it is important to pay attention to the screening of this disease.