Patients with acromegaly have a poor prognosis and tend to die within 3-5 years from respiratory muscle paralysis or lung infections, with a small number of patients surviving for more than 10 years. Acromegaly, also known as amyotrophic lateral sclerosis, is the most common type of motor neuron disease, with an age of onset of 30-60 years, mostly over 45 years. It is more common in men than in women. The first presentation is clumsiness and weakness of the fingers on one or both hands, followed by atrophy of the small muscles of the hand. As the disease progresses, muscle weakness and atrophy extend to the trunk and neck. Late in the course of the disease, tongue muscle involvement may occur, manifesting as slurred speech, difficulty swallowing, and weakness in chewing. Eventually most patients will die within 3-5 years from respiratory muscle paralysis or lung infections. There is no specific medicine for acromegaly, and its treatment mainly includes neuroprotection and symptomatic treatment. Patients should pay attention to cold protection and avoid getting cold in daily life. Patients who are bedridden should also strengthen care and turn more often to prevent complications such as venous thrombosis of the lower limbs and decubitus ulcers.