It is a rare disease with no obvious symptoms in the early stages of the disease, followed by muscle weakness, myasthenia gravis and pyramidal fasciculus signs. A small percentage of atypical patients may develop dementia and sensory abnormalities that can affect limb movement. The main manifestations of acromegaly are the following: 1. muscle weakness and myasthenia gravis: muscle weakness and myasthenia gravis can lead to clumsy and weak finger movements on one or both sides. If the patient’s condition continues to worsen, the hand muscles will undergo severe atrophy, especially the size of the interphalangeal muscle is most obviously damaged. As the disease progresses, the patient’s hands may develop an eagle’s claw shape, which may extend to many parts of the forearm and upper arm, making the disease more severe. In addition, it will also affect the function of the pharyngeal area, which will produce different degrees of muscle atrophy and weakness symptoms, leading to dysphagia, speech difficulties, respiratory difficulties and even respiratory failure; 2. Myofascicular tremor: the site of motor neuron damage will produce obvious symptoms of myofascicular tremor; 3. Pyramidal bundle signs: lesions involving the pyramidal bundle will appear spastic paralysis, hyperreflexia and positive pathological signs; 4. Other symptoms. A small proportion of patients may show manifestations other than the motor system, such as dementia, extrapyramidal symptoms, sensory abnormalities and vesicorectal dysfunction, etc. A small proportion of patients may also show extraocular muscle movement disorders, and it is clinically customary to refer to acromegaly with the above rare manifestations as atypical motor neuron disease.