Before the introduction of hepatitis B vaccination, China used to be a country where hepatitis B was prevalent. To this day, there are still many people who talk about “major third-positive” and “minor third-positive”, so what is “major third-positive” and “minor third-positive”? “What is the difference between them? What is the difference and connection between the two? If you become a colleague with a person who has “major and minor triplets”, will you unknowingly contract hepatitis B (hereinafter referred to as hepatitis B)? The relationship between “major and minor tri-positive” and “two-and-a-half” is clear. are the two most common results of the hepatitis B virus (HBV) “two-and-a-half” test. The first pair refers to hepatitis B surface antigen (HBsAg) and surface antibody (anti-HBs), the second pair is E antigen (HBeAg) and E antibody (anti-HBe), and the third pair is core antibody (anti-HBc) and core antigen (HBcAg). As the core antigens in the liver cells have all been assembled into hepatitis B virus, the free core antigens cannot be detected in the serum, so only half of the third pair (i.e. anti-HBc) can be detected in the peripheral blood, hence the term “two and a half pairs”. The so-called “big three” is HBsAg, HBeAg, anti-HBc are positive, that is, the first, 3, 5 positive; “small three” refers to HBsAg, anti-HBe, anti-HBc three positive, that is, the first, 4, 5 positive. The “major and minor triple-positive” people are not necessarily hepatitis B patients The test results of “major triple-positive” and “minor triple-positive” only indicate that they are infected with hepatitis B virus or carry hepatitis B virus, and cannot be diagnosed as hepatitis B on this basis. It is not a diagnosis of hepatitis B. “According to the hepatitis B virus deoxyribonucleic acid (HBV-DNA), liver function, imaging and clinical symptoms, there are roughly two types of cases: the first case, whether “major triple-positive” or “If the liver function and imaging tests are normal and there are no obvious symptoms, they are called hepatitis B virus carriers and cannot be diagnosed as hepatitis B patients and are not suitable for drug treatment. In the second case, whether it is “major tri-positive” or “minor tri-positive”, if the liver function is repeatedly abnormal, or if there are clinical symptoms, or if there is hepatosplenomegaly, etc., the patient should be judged as a hepatitis B patient and needs active treatment to control the active liver disease as soon as possible. The condition of a person infected with the hepatitis B virus is determined not by whether the person has “minor” or “major” hepatitis B, but rather by whether the person has impaired liver function. Some people with “major triple-positive” wish to become “minor triple-positive” and even use some drugs, but this is not necessary. This is because “major and minor triple-positive” is a figure that reflects the number and activity of the hepatitis B virus in the body, and only reflects the status of the virus carried in the body, but does not reflect the normal function of the liver or not, and whether liver function is damaged and the degree of damage is not directly related to the degree of virus replication, so it cannot be used to determine the severity of the disease. In order to understand the liver function, it is best to go to a regular specialist hospital for liver function and liver ultrasound tests on a regular basis (3 months to 6 months). “Many people believe that “small triplets” are better than “big triplets” and are not contagious. The most important thing is that it is better and not contagious. Professor Su pointed out that such a concept is wrong. The “small three yang” is still contagious, but usually the virus content in the blood circulation of the “small three yang” is relatively low. It is generally believed that “major triple-positive” means that the virus is actively replicating, often accompanied by positive HBV-DNA, which means that it is highly contagious and has a greater likelihood of becoming chronic hepatitis B. There are two types of “minor triple-positive”: one is usually the result of “major triple-positive”, which means that the body has developed a certain degree of immunity against the E antigen, indicating that the virus has basically stopped replicating, and if the HBV-DNA is negative, it is less infectious. The other is that the infected hepatitis B virus may have mutated and cannot express the E antigen, but the HBV-DNA is still positive, indicating the existence of viraemia, which is still contagious, and the disease may be heavier and develop faster, so attention should be paid. Usually, “major triple-positive” people pay more attention to their condition, so many advanced liver diseases such as cirrhosis and liver cancer that exist in this group are more easily detected in time. In contrast, “small triplets” are often neglected because they are less contagious, including the patients themselves, who are prone to slackness, and their advanced liver disease is relatively less likely to be detected, resulting in more serious consequences than “large triplets”. “The most important thing to note is that, in general, regardless of whether it is a “major triplet” or a “minor triplet”, if the liver function and imaging tests are normal, there is no need for special treatment. For those who have a family history of hepatitis B, are older than 40 years old and have normal liver function, liver aspiration biopsy can be performed if necessary to clarify the inflammation and fibrosis of the liver. If liver function is found to be abnormal, it is necessary to go to a regular specialist hospital for treatment in a timely manner. In life, we should pay attention to the strict prohibition of alcohol to protect the liver, usually to combine work and rest, happy spirit, regular life and reasonable diet. Be alert to hepatitis attacks caused by decreased body resistance, anger, exertion and other triggers. If there are medications should be carried out under the guidance of a doctor, do not have a disease, abuse drugs, should not change the medication too diligently. “If you have a wound or a break in your body, you should avoid getting wound secretions on public items. The general contact with the “major and minor tri-positive” people will not be infected Since the “major and minor tri-positive” people have the hepatitis B virus, we should not stay away from them to be safe? In response to this concern, Professor Su pointed out that general contact with people with “major and minor triplets”, such as shaking hands, eating at the same table, talking face to face, etc., will not transmit the hepatitis B virus. The transmission of hepatitis B virus is mainly through blood, mother to child, sexual contact and other means of transmission. The prerequisite for the hepatitis B virus to be transmitted from the virus or infected person to other people is that a certain amount of virus needs to enter the blood of a healthy person through broken skin and mucous membranes, while the above-mentioned situation generally does not occur when labor tools and office items are shared among colleagues. There are also some people in the adult population who have acquired immunity against the hepatitis B virus due to “recessive infection”, meaning that these people have unknowingly been infected with the hepatitis B virus, and although they do not have obvious symptoms, their bodies have developed antibodies as a result and are less likely to be infected with the hepatitis B virus. Professor Su reminded the public, in order to prevent infection with hepatitis B, can check the “two pairs of half”, antibody-negative people can be standardized vaccination against hepatitis B to obtain immunity, which is also the most effective measures to prevent infection. At the same time, it is important to develop good hygiene habits in life, avoid premarital and extramarital sex, avoid sharing syringes and intravenous drug use, avoid illegal clinics and medical units that are not strictly sterilized, do not receive blood transfusions or blood products, do not share personal items such as razors and toothbrushes with others, do not accept shaving, pedicures, tattoos and other services that may scratch the mucous membrane of the skin in units that are not strictly sterilized. You should wear gloves when touching the blood of hepatitis B patients and those with “major and minor triple-positive”. Pregnant women and mothers with “major and minor triplets” should consult their doctors and take the necessary measures to prevent the transmission of the virus to the fetus or baby.