Because ankylosing spondylitis is a relatively common disease with a prolonged course and a tendency to cause disability, early diagnosis and treatment should be sought. Young people aged 16-25, especially young men, should be particularly alert to the possibility of ankylosing spondylitis if the following symptoms occur 1, low back pain and lumbar stiffness for more than 3 months, which cannot be relieved by rest. 2, unilateral or bilateral sciatica, no obvious history of trauma or sprain. 3.Recurrent episodes of knee or ankle joint swelling and pain, joint effusion, without obvious history of trauma or infection. 4.Recurrent episodes of heel node swelling and pain or heel pain. 5.Recurrent episodes of iritis. 6.No cough and other respiratory symptoms, chest pain and girdling sensation without history of trauma, and limited thoracic movement. 7.Spinal pain, stiffness, and even limited activity function without obvious history of trauma or sprain. 8.Bilateral hip and hip joint pain without obvious history of trauma or strain. 9. Sudden onset of pain, swelling, and activity dysfunction in the large joints of the spine and extremities. Ankylosing spondylitis is generally insidious in its onset and may not have any clinical symptoms in the early stages. Some patients may show mild systemic symptoms in the early stages, such as weakness, wasting, chronic or intermittent low fever, anorexia, mild anemia, etc. The patient’s condition is usually not detected at an early stage, resulting in delay and loss of the best time for treatment.