The time to turn negative after syphilis treatment cannot be generalized and is related to syphilis staging, personal constitution, response to treatment, etc. Generally speaking, through timely and effective treatment, syphilis TRUST titer has more than 4 times decrease and continues to decrease to less than 1:8, and the test results are negative every 3 months, and continued monitoring is sufficient, then there is no need to maintain treatment; as long as the infection has been syphilis, even if it has been cured, the TPPA indicator may remain positive for life and will no longer turn negative.