For syphilis standardized treatment is very important, follow-up is also very important, syphilis patients should be followed up regularly after adequate treatment, including general physical examination and non-spirochete antigen serological test (RPR) to understand whether the cure or recurrence. 1, early syphilis: review every 3 months in the first year after treatment, and every 6 months thereafter for 2 to 3 years. Most of the RPR can turn negative within 1 year for stage 1 syphilis and within 2 years for stage 2 syphilis. If the RPR turns negative to positive or the titer increases 4 times, which is serum relapse, or if there is symptomatic relapse, the amount of retreatment should be doubled. If the RPR does not turn negative for more than 2 years, it is serum fixation, and if there is no clinical symptom recurrence, whether to retreat or not is determined on a case-by-case basis. Regardless of serologic relapse or serum fixation, or whether to retreat or not, HIV examination and neurological examination should be done for early detection of HIV infection or asymptomatic neurosyphilis. 2. Late syphilis: the review after treatment is the same as early syphilis, but should be continuously observed for 3 years. A few late syphilis sera can be sustained on low titers (more than 3 years of follow-up) can be judged as serum fixation. HIV test, neurological examination and cerebrospinal fluid examination should be done. Neurosyphilis should be followed up with cerebrospinal fluid every six months until the cerebrospinal fluid is completely turned to normal. 3, pregnancy syphilis: monthly recheck syphilis seropositivity before delivery, and observation after delivery as other syphilis. However, the baby born should be observed until the serum is negative, if the titer is found to increase or symptoms occur, treatment should be carried out immediately. 4. Cardiovascular syphilis and neurosyphilis should be followed up for life by the relevant specialist.