Gallbladder cancer is the most common malignant lesion of the biliary tract and is more common in women aged 50-70 years. Primary gallbladder cancer ranks fifth in incidence and second in mortality rate of gastrointestinal tumors. Due to the absence of symptoms and signs in early stage of gallbladder cancer, the lack of specific tumor markers and the history of chronic cholecystitis and gallbladder stones in most patients with gallbladder cancer, the diagnosis rate of early stage gallbladder cancer is very low, and once diagnosed, most of the disease is late and the prognosis is very poor. Therefore, it is especially important to pay attention to high-risk factors of gallbladder cancer for early diagnosis and early treatment. High-risk factors of gallbladder cancer include: 1. age: patients over 60 years old with a history of gallbladder stones >10 years; 2. gender: the incidence of gallbladder cancer is significantly higher in women than in men, and the ratio between them is about 3:1; 3. gallbladder stones: about 80% of gallbladder cancer patients have gallbladder stones in combination. The incidence of gallbladder cancer in patients with gallbladder stones is 7 times higher than that in patients without stones; 4.Stone diameter: gallbladder stones >2cm in diameter or stones embedded in the neck of gallbladder are prone to gallbladder cancer; 5.Gallbladder lesions: blurred outline of gallbladder, gallbladder atrophy, local thickening or irregularity of gallbladder wall, porcelain-like gallbladder and gallbladder bulging lesions (diameter >lcm); 6.Heredity: family history of gallbladder cancer. Most of the tumors have hereditary tendency. Patients with the above high-risk factors should go to hospital for consultation and treatment in time. Key points of early diagnosis of gallbladder cancer: 1. No specific symptoms in early stage. There may be gallstone symptoms such as pain and discomfort in the right upper abdomen, anorexia and indigestion. More than half of the patients have history of biliary colic or acute cholecystitis; physical examination or physical signs of cholecystitis and biliary colic; 2. Laboratory tests: carcinoembryonic antigen (CEA) and glycogen chain antigen 19-9 (CA19-9) in serum and bile have certain positive rates, which are helpful for early diagnosis, especially the positive rate of CA19-9 can reach 81.3%, but the specificity of both is poor; 3. Imaging examination: ultrasound examination is preferred. If blurred gallbladder outline, gallbladder atrophy, local thickening or irregularity of gallbladder wall, porcelain-like gallbladder, gallbladder bulging lesion (diameter >lcm) are found, CT examination of upper abdomen combined with tumor marker examination should be performed in time for careful screening and follow-up.