Sternal pain is often considered rib fractures, gastroesophageal reflux, leukemia, etc., and can be treated with medication, surgery, etc., and the use of medication should be in accordance with the doctor’s instructions. 1. Rib fracture: rib fracture caused by impact or extrusion injury, etc. Non-steroidal anti-inflammatory drugs, such as ibuprofen, can be used if the pain is severe. For non-displaced fractures, pain relief and bed rest should be the mainstay. For displaced fractures, conservative treatment with closed reduction can be tried. Surgery can be considered if necessary. 2. Gastroesophageal reflux: caused by reflux of gastric contents, it can be treated with proton pump inhibitors, such as omeprazole, etc., gastric stimulating drugs, such as domperidone tablets, etc., and gastric mucous membrane protectants, such as magnesium aluminum carbonate. 3. Leukemia: due to the large proliferation of leukemia cells in the bone marrow caused by increased volume pressure in the bone marrow cavity, interferon, methotrexate, granulocyte colony-stimulating factor and other drugs can be used for treatment. Bone marrow transplantation and peripheral blood stem cell transplantation can also be considered. Sternal pain can also be seen in other diseases, and it is recommended that patients go to the hospital in time to identify the cause and timely treatment.