Pharmacogenic liver damage is liver damage that occurs during or after drug therapy for a disease, and can manifest as inflammatory changes in liver cells, cholestasis, steatosis, or even or cirrhosis. There is a wide variety of drugs that can cause different liver damage, about 200 or more, including non-steroidal antipyretic and analgesic drugs (such as acetaminophen), muscle relaxants, anesthetics, anticonvulsants, antibiotics, antifungal and antiparasitic drugs, antitubercular drugs, anticancer and immunosuppressive drugs, hormonal drugs, oral hypoglycemic drugs, antithyroid drugs, H2-blockers, psychiatric drugs and so on. Individual drugs progress insidiously until cirrhosis, such as methotrexate. Drug-induced damage can be classified as predictable, usually dose-related, and non-predictable, often dose-independent. The current hepatotoxic effects of herbal medicines must be further properly understood, both to avoid blind exaggeration and to overcome the notion that herbal medicines are non-toxic. The results of our study showed that some herbal medicines commonly used in liver diseases, such as Trigonella and Curcuma, can cause liver damage at high doses, but their toxicity decreases or even has no hepatotoxic side effects after correct compounding. However, more information is needed to be confirmed by a large number of studies. Once drug-related liver damage occurs, the drug should be discontinued immediately or suspected. The liver protector such as reducing glutathione can be applied. For drug-related cirrhosis, the focus is on prevention and prevention of early drug-related damage, such as liver function should be measured regularly during treatment with drugs, and in patients with pre-existing liver or kidney disease, the changes in liver function during drug use should be monitored. Those who have a history of drug-related liver damage should avoid using the same or chemically similar drugs again.