Ankylosing spondylitis is a chronic and relapsing rheumatic disease, so regular follow-up with a regular rheumatologist is a homework that patients must do regularly, if the disease activity is generally recommended 1-2 months to review once, if the disease is stable is generally recommended 3-6 months to review once, the review program, of course, and other rheumatic diseases include two aspects: evaluation of efficacy and monitoring side effects, of which urinary routine is the most The most common type of pathology is IgA nephropathy, manifested as hematuria and/or proteinuria, or even renal insufficiency with elevated creatinine, which can of course also occur The most common type of pathology used in patients with advanced disease is amyloidosis. 2, urinary abnormalities can be the cause of this group of diseases: in the case of strict pursuit of medical history, about seventy percent of the occurrence, exacerbation or recurrence of spondyloarthritis or ankylosing spondylitis are related to urinary or gastrointestinal tract infections, detection of the presence of urinary sensation for the treatment of the disease will be of great help. There is also a type of spondyloarthritis called reactive arthritis and urinary tract infection is more closely related, although anti-infective treatment does not have definite evidence to prevent the occurrence and development of the disease, but for a small number of patients is still meaningful. 3, urinary abnormalities is one of the most common side effects of drugs: such as non-steroidal anti-inflammatory drugs is currently the most effective class of therapeutic drugs, the side effects include kidney damage, this side effect generally has two types, one is hypersensitivity reactive, as soon as the exposure immediately, within 1-3 days of proteinuria, hematuria or tubular urine leukocytes urine, a cumulative if a long-term mass application of a drug More than 10 years, a kind of analgesic nephropathy can appear, with interstitial damage dominated by renal insufficiency, etc. Another drug most commonly used to treat this group of diseases is salazosulfapyridine, oral salazosulfapyridine if you can not ensure adequate water intake, can appear sulfa drug renal damage, of course, there will be hypersensitivity reactive renal damage in sensitive individuals, these are to be alert, although the incidence is very low, most patients are safe to apply, but must be vigilant, once the appearance of the treatment plan should be adjusted in a timely manner, and the test urine routine is an easy and economical means. Therefore, patients who receive drug therapy or are about to receive drug therapy should be tested regularly for urine routine to detect renal damage and deal with it in time.