The survival period of motor neuron disease varies from person to person, ranging from a few months to more than 10 years, and cannot be generalized. Most of the early symptoms of motor neuron disease are not obvious, first of all, there may be inflexibility and weakness of the fingers, with ipsilateral wrist extension difficulties, some patients may gradually appear spastic paralysis of the lower limbs, scissor gait, etc. The medullary palsy usually appears later, there may be subjective sensory impairment of the limbs, but even in the late stage of the disease, there is no objective sensory impairment, the disease continues to progress, and eventually due to The disease continues to progress and eventually dies due to respiratory paralysis or complications of respiratory infections. Treatment consists of etiologic therapy, symptomatic treatment and various non-pharmacologic supportive treatments. Once the motor neuron disease occurs, the diagnosis and differential diagnosis should be examined promptly, neuroprotective and supportive treatment should be given as early as possible, and regular follow-up should be adhered to.