The symptoms of motor neuron disease at the end of life mainly refer to the paralysis of respiratory muscles when the patient reaches the late stage of the disease, the patient suffers from wheezing and difficulty in breathing effectively, and the patient develops hypoxemia, which eventually leads to death. If the patient uses a ventilator to assist breathing, he or she is also prone to respiratory infections and death. Motor neuron disease is a disease of unknown cause, mainly due to the simultaneous involvement of upper and lower motor neurons, and the patient develops muscle weakness, myasthenia gravis, and finally paralysis of respiratory muscles. The first symptom of myasthenia gravis is weakness of one limb, and as the disease progresses, the patient may develop tremor of the muscle bundles and medullary paralysis, which may manifest as dysarthria, slurred speech, difficulty in swallowing or chewing. Finally, in the later stages of the disease, the patient develops respiratory muscle paralysis, and the patient exhibits wheezing, and if necessary, tracheal intubation and ventilator assisted breathing can be given. However, subsequent bed rest can lead to pressure sores and infections, which can eventually lead to death.