If transaminases are too low, are they not suitable for treatment? Yes, transaminases below 2 times the upper limit of normal are not suitable for antiviral therapy unless there is progression on ultrasound or liver pathology. If the aminotransferase is too high, do I need to lower the enzyme first before I can inject interferon? Yes, transaminases above 10 times the upper limit of normal require enzyme-lowering therapy before interferon therapy can be administered. Do I need to take nucleoside analogs before interferon injection? Usually not, unless the viral count is very high, e.g. more than 10 to the sixth power. Is it better to inject interferon alone or to combine it with nucleoside analogues? This depends on the circumstances. Generally speaking, once a nucleoside analogue is started, it cannot be stopped. So, is it possible to stop taking interferon? Interferon can be discontinued. Is there a problem with interferon causing resistance and viral mutation? Rarely. If you stop taking interferon for some reason, do you continue to take it? Generally speaking, after interferon is not effective, can I switch to oral medication? Is it possible to switch to interferon after taking the medication for a period of time? If the effect of interferon is not obvious, you can change to oral medication. Once you have taken the medication, it is generally not recommended to change to interferon.