Usually, how long a patient can live with diffuse liver lesions is determined by the type of lesion and cannot be generalized. Depending on the type of lesion, if the patient has alcoholic hepatitis or steatohepatitis, the patient needs to stop drinking, eat a light diet, and after regular treatment and good lifestyle habits, the patient can improve faster and will not affect his life expectancy. If it is viral hepatitis, liver preservation treatment should be accompanied by standardized antiviral treatment, and after active and regular treatment, patients can obtain long-term survival and survive for 10, 20 or even longer years. If it is drug-related liver injury, stop applying drugs that damage the liver and receive liver-protective treatment can get better soon and will not affect the patient’s life expectancy. In case of hepatocellular carcinoma, the patient’s life expectancy should be judged according to the doctor’s diagnosis and treatment, and it is impossible to judge the absolute life expectancy. Patients with diffuse liver lesions should lead a regular life, stop smoking and drinking, eat more fresh vegetables and fruits, and have regular checkups.