In the advanced stages of ankylosing spondylitis, ultramicroscopy with holmium laser can also achieve a full release. The ultramicroscopic treatment technology has introduced and improved the arthroscopic technology of modern medicine in the external treatment of Chinese medicine, visualizing and minimizing the external treatment, which is another powerful tool for clinical diagnosis and treatment of ankylosing spondylitis bone disease. The first pathological changes in ankylosing spondylitis joints are synovitis, which is the earliest pathological change in ankylosing spondylitis-involved joints, where inflamed synovial tissue is seen under the microscope as hyperplasia, villi formation, and infiltration of plasma cells and lymphocytes around small blood vessels. This inflamed synovial tissue can release inflammatory mediators, causing painful swelling of the joint; it can release a variety of enzymes, destroying joint cartilage and bone tissue and eventually causing joint destruction. The lesions mostly start in the sacroiliac joints and gradually invade upward to the lumbar, thoracic and cervical spine. The shoulder joint, temporomandibular joint, transverse rib joint, cribriform joint, sternoclavicular joint, sternoclavicular stalk joint, and pubic symphysis are also often involved. This is a characteristic pathology of ankylosing spondylitis, in which aseptic inflammation occurs at the attachment sites of ligaments, tendons and joint capsules, and the granulation tissue generated during the inflammatory process can destroy cancellous bone. During the process of bone tissue repair, the inflammatory process stimulates excessive bone production, and the new bone tissue not only fills the bone defects, but also extends into the nearby ligaments, tendons, and joint capsule, forming a violated bone flank. This characteristic inflammation of the tendon end is mostly seen in the sciatic tuberosity, heel tuberosity, pubic symphysis, iliac crest, and greater trochanter of the femur. The most important thing is that the spinal cord is not only a part of the body, but also a part of the body. This change in the spine is the pathological basis for the bamboo-like changes on the X-ray. The operation of ultramicroscopy: operation experience: ultramicroscopy treatment operation incision is small, little side injury, less intraoperative bleeding, generally can be carried out under local anesthesia, no blood transfusion and additional tourniquet, treatment can be injected into the joint through the tube of physiological saline (containing Zhengqing wind pain Ning and other injections) to expand the joint cavity (saline bottle hanging height is generally about 1m above the knee joint), to maintain a clear surgical field. After routine disinfection and towel laying, a small incision of about 0.5 cm was made in the skin, and then a trocar needle matching the diameter of the ultramicroscope was used to puncture, remove the sharp occluder and replace it with a blunt occluder, insert the ultramicroscope into the joint cavity, adjust the operative field, and carry out observation in sequence. Taking the knee joint as an example, the sequence is as follows: suprapatellar synovial crease – patellofemoral joint – medial crypt (medial medial wall, medial patellar synovial crease, crypt surface of the medial ankle) – medial tibiofemoral joint (medial meniscus, below the anterior aspect of the medial femoral ankle and the relative tibiofemoral articular surface) -then to the suprapatellar capsule – lateral tibiofemoral joint (lateral meniscus, anterior underside of the lateral femoral ankle and relative crypt facets) – lateral crypt (lateral medial wall, crypt facets of the lateral femoral condyles, muscle health). What is seen above can be photographed or videotaped. While observing, the injured tissue is treated with stripping, loosening and cutting, while the joint cavity is continuously lavaged with saline containing herbal injection, and finally biopsy can be made, and after lavage and draining of the filled fluid, the preparation of retardant can be left in place, the trocar needle is withdrawn, and the skin incision is sutured. Within 12 to 24 hours after ultramicroscopy treatment, there is a heavy feeling and mild pain, which gradually disappears later. Some patients develop reactive effusion, which is related to the original lesion and usually disappears within 2 to 7 days; if the treatment tissue is extensive, it may cause bleeding;, microscopic surgery for more than 2 hours may produce symptoms similar to traumatic arthritis, but it may disappear within a short time. Strenuous activities should be avoided for 24 hours after surgery, and functional recovery activities can be performed after 24 hours. ”HLR” technique for synovectomy: The first in China to use HLR technique to completely remove the hyperplastic synovial tissue, which rapidly relieves the symptoms and greatly reduces the recurrence rate of the disease. AVM technology: Combined with AVM technology, it can consolidate the above treatment, improve the cure rate, reduce the risk of surgery, and reduce recurrence. Triple Oxygen Big Autologous Blood Therapy: A medical treatment in which one’s own blood is drawn out and reinjected back into one’s body. It is divided into small autologous blood and large autologous blood therapy depending on the amount of blood and the injection site. It is the most widely used autologous blood therapy at home and abroad, which involves the treatment of triple oxygen oxidation of the drawn blood and then injecting it back into the body.