The detailed etiology of ankylosing spondylitis is unknown, but it is related to genetic genes, and is often associated with viral and bacterial infections in the early stages of the disease, which mainly involves periarticular muscle tissue and ligaments, with inflammatory edema, cellular fluid exudation, and toxin stimulation of peripheral nerve endings, resulting in muscle spasm and pain or morning stiffness. Due to improper treatment and prolonged history of the disease, the inflammatory edema of the periarticular tissues gradually disappears, the muscle cells gradually become fibrotic, fuse with the cartilage and ossify, and the joints become seriously impaired. Ankylosing spondylitis is more common in adolescents and is more common in men than in women. Because of its slow onset, some symptoms are atypical and often lead to misdiagnosis. The main clinical manifestations of the disease are low back pain and morning stiffness. Some patients may also show peripheral joint pain, such as knee and ankle pain, which is often characterized by increased pain at night and in the morning, and significantly reduced after activity. The presence of this symptom should raise the alert. In terms of diagnosis, close combination of sacroiliac joint X-ray, CT film, HLA-B27, blood sedimentation, C-reactive protein, etc. should be used to clarify the diagnosis. In the early stage of the disease, the application of Chinese herbal medicine is based on clearing heat and detoxifying, cleaning phlegm and dispersing knots through evidence-based treatment; in the late stage of the disease, it is based on supporting the righteousness and eliminating evil, tonifying kidney and filling essence, activating blood circulation and removing stagnation, and it is proved that such Chinese herbal medicine can have good therapeutic effects by regulating autoimmune function, eliminating immune complexes and eliminating inflammatory lesions of ligamentous muscle tissue, which can achieve clinical cure in the early stage, and play a role in blocking the proliferation of muscle fiber tissue in the middle and late stage patients It can achieve clinical cure in the early stage and block myofibrillar tissue proliferation in the middle and late stage patients, block ossification, restore part of the bone and joint function, and improve the quality of life of patients.