The human body is like an amazing machine, when a part of this machine has a problem, the body will appear some small conditions to alert our attention. However, the busy life of every day make you ignore these health alerts? Lifehacker has searched for comprehensive disease knowledge for you busy people, hoping to make your every day a healthy and happy one. The time and severity of the symptoms of organophosphorus pesticide poisoning are closely related to the route of entry, the nature of the pesticide, the amount of entry and absorption, and the health condition of the human body. Inhalation and oral intake of highly concentrated or highly toxic organophosphorus pesticides can lead to symptoms and death within a few minutes. Skin contact poisoning has a slower onset, but can show serious symptoms after absorption. Early or mild cases of this type of pesticide poisoning may show dizziness, headache, nausea, vomiting, salivation, excessive sweating, blurred vision, and weakness. In addition to the above-mentioned symptoms, more severe cases have narrow pupils, muscle tremors, lacrimation, increased bronchial secretions, dry and wet rales and croup in the lungs, abdominal pain, diarrhea, confusion, staggering, bradycardia, fever, chills, etc. In severe cases, there are often abnormal heart rhythm such as tachycardia, atrioventricular block and atrial fibrillation, increased or decreased blood pressure, cyanosis, dyspnea, froth at the mouth and nose or even with blood (pulmonary edema), convulsions, coma, incontinence or urinary retention, paralysis of the limbs, loss of reflexes, etc. Death may occur due to respiratory paralysis or with circulatory failure. Inhalation poisoning patients, respiratory and eye symptoms appear earlier, oral poisoning often occurs first gastrointestinal symptoms, skin contact poisoning with local sweating and contraction of adjacent muscle fibers as the initial manifestation, dichlorvos and skin contact more erythema-like changes, gradually become blisters, the child has itching, burning sensation. The clinical manifestations of pediatric organophosphorus poisoning are sometimes atypical: some children mainly show neurological symptoms such as headache, vomiting, hallucinations, convulsions and coma; others mainly show digestive symptoms such as vomiting, abdominal pain and dehydration; others mainly show circulatory symptoms such as slowed or increased heart rate, decreased blood pressure and shock; others mainly show respiratory symptoms such as fever, shortness of breath, sputum and pulmonary symptoms. Occasionally, some children with poisoning only have single symptoms or signs as the main manifestation, such as high fever, abdominal pain, convulsions, limb weakness, unstable walking, resulting in tumbling and falling, generalized swelling with routine changes in urine, etc. Therefore, the clinical diagnosis is sometimes misdiagnosed as encephalitis, meningitis, acute gastroenteritis, intestinal ascariasis, toxic dysentery, pediatric or neonatal pneumonia, nephritis, epilepsy, acute infectious polyneuritis, drug (such as barbiturates, opioids, chlorpromazine, chloral hydrate) poisoning, etc. For suspected cases, we must thoroughly inquire about the history of contact with organophosphorus pesticides, and have a thorough understanding of the child’s food (breastfeeding), lodging, clothing, exposure and playgrounds; carefully check whether the child has any specific signs of organophosphorus pesticide poisoning, such as pupil narrowing (may not appear in the early stages of poisoning, but the pupils are dilated in the late stages; occasionally, children with poisoning do not have pupil narrowing, or have a transient dilatation before pupil narrowing), muscle bundle Tremor, increased secretions such as sweating, salivation, lacrimation, pulmonary rales (acute pulmonary edema), skin erythema or blisters, etc. Some organophosphorus pesticides have a special garlic odor or aromatic smell. According to laboratory conditions, the following tests can be done: ① test the patient’s vomit or stomach contents taken for the first time during gastric lavage, as well as respiratory secretions, can prove the presence of organophosphorus compounds. ② Determination of organophosphorus breakdown products in urine can be used as an indicator of exposure to toxins, some and can assist in early diagnosis. ③The determination of blood cholinesterase activity, if the cholinesterase activity is reduced to less than 80% of normal, it has diagnostic significance, and the value can be used to estimate the mildness of poisoning and as a reference for medication. In mild cases, blood cholinesterase activity drops to 70% to 50% of normal, in moderate cases it reaches 50% to 30%, and in severe cases it is below 30%. In rural areas and rescue sites, the approximate results of cholinesterase activity can be determined within 20 minutes by using the simple and applicable bromomuscovitol blue paper colorimetric method.