1. Maintain vital signs. Immediately after the patient is admitted to ICU, monitor and determine respiration and circulation. If respiratory failure, immediately perform tracheal intubation and mechanical ventilation; hypotension with norepinephrine to raise the pressure. 2. Thoroughly remove the poison. Remove clothing, scrub the torso and limbs, rinse the mouth, and repeatedly wash the stomach if necessary. 3.Take detailed medical history. (2) Clinical symptoms such as vomiting, impaired consciousness, and time of appearance; (3) Time of hospitalization, gastric lavage, gastric lavage dose, time of medication, drug name, and dose; (4) Time of transfer to hospital, condition at the time of transfer, and condition during transfer; including changes in condition and treatment during transfer. 4. Detailed physical examination. Including consciousness, pupils, various reflexes, oral cavity, heart, lungs and abdomen, limbs and skin, etc. 5.Perfect relevant examinations. Including blood gas, cholinesterase, blood routine, liver and kidney function, bedside chest X-ray, etc. 6.Determine atropinization. The manifestations of atropinization include dry mouth, flushing of the face, dry skin, coarse lung Аmu (12) about 100 times/min, and body temperature 37.3-37.5℃. 7. Determine the drug regimen. The vast majority of patients coming to ICU have already used a certain amount of atropine or long tonic, as well as reenergizing agents, so the medication is generally considered in terms of repeated doses and maintenance doses. ①If muscarinic symptoms are still present, intramuscular long tonic 1~2mg. assess whether atropinization is achieved every 0.5~1 hour, and repeat 1~2mg if not achieved until atropinization is achieved. (ii) If atropinization is achieved but ChE<50%, maintain with long tonicin 1~2mg, q8~12h; recheck che every 12~24 hours during medication, stop medication for observation if che>50%. ③ If only nicotine-like symptoms and ChE<50%, then repeat intravenous injection of chlorophosphamide 1.0g, after which the drug can be stopped for observation by 5~8 che="">50%. 8. Proper mechanical ventilation. Patients with nicotine-like symptoms or intermediate syndrome are advocated to actively and actively establish an artificial airway and perform mechanical ventilation as early as possible. In addition to consciousness, ventilator parameters in line with extubation conditions, and exclusion of airway obstruction, ChE activity is an important indicator for stopping extubation. The first three indicators and ChE>50% can be considered for extubation. 9. Timely blood perfusion. In addition to early and timely blood perfusion, for patients with moderate or severe poisoning, repeated blood perfusion can prevent the rebound of poisoning because of the possible re-release of residual toxicants into the blood. 10. Support symptomatic treatment. Strengthen nutritional support, adjust the internal environment, prevent lung infection, protect liver and kidney function, etc.