Whether gallbladder atrophy will develop cancer and how soon it will become cancerous cannot be generalized and is related to the specific etiology causing gallbladder atrophy In fact, many gallbladder system diseases can cause the symptomatic manifestation of gallbladder atrophy, which can be divided into two major types according to the type of disease: infectious as well as non-infectious. Among them, infection of the gallbladder tissue with sensitive bacteria is a common cause of gallbladder inflammation, including Klebsiella, Streptococcus haemolyticus and Clostridium perfringens. Patients with such conditions can be treated with targeted antibiotics as well as other types of drugs to achieve complete cure without cancer. For non-infectious causes of gallbladder atrophy, such as gallbladder stones, gallbladder cholesterol deposits, gallbladder polyps, etc., we need to consider surgical treatment and medication to reduce the risk of cancer, taking into account the actual type of disease and pathological stage of patients. For patients with gallbladder atrophy, the principle of early detection and early intervention should be adopted. In addition, the daily diet should follow a light form of diet and reduce the intake of fat and cholesterol, which can prevent the deterioration of the disease.