Symptoms of peripheral neuropathy include sensory disturbances, movement disorders, etc. In order to make a definitive diagnosis of peripheral neuropathy, a physical examination, blood biochemistry, urine metallometry, cerebrospinal fluid examination, and genetic testing are usually required. Peripheral neuropathy has many characteristic symptoms, such as sensory disorders, motor disorders, autonomic dysfunction and other symptoms. In addition, due to the different causes of peripheral neuropathy, there may also be manifestations of the primary disease. 1. Physical examination: focusing on the examination of the nervous system, observing whether there is any tendon reflex weakening or disappearing, whether there is any abnormality in muscle tone and muscle strength, whether there is any sensory disorder and motor disorder. 2. Blood biochemistry examination: blood sugar and vitamin B12 levels should be tested to check for metabolic disorders. 3. Urine metal determination: if the patient is suspected to have heavy metal poisoning, the content of all kinds of heavy metals in urine should be determined. 4. Cerebrospinal fluid examination: increased protein and cell count suggests nerve root or spinal membrane lesions. 5. Genetic testing: helps in the diagnosis of hereditary peripheral neuropathies such as peroneal muscular dystrophy. According to the description of the patient’s medical history and the presence or absence of typical symptoms, combined with physical examination, blood biochemistry tests and other test results, a clear diagnosis can usually be made. Diagnosis should be made under the guidance of a doctor, not blindly on your own to avoid affecting your condition.