Peripheral nerve patients with headache is generally not related to peripheral neuropathy itself, the main cause of headache treatment, such as primary headache oral pain medication, such as ibuprofen, etc.; hypertension oral antihypertensive drugs, such as amlodipine benzenesulfonate; intracranial space-occupying lesions, such as intracranial tumors, such as surgical treatment. 1. Primary headache: Migraine patients take oral ibuprofen and sumatriptan as prescribed by the doctor. Tension headache using diclofenac sodium, ibuprofen and other drugs. 2. Hypertension: when the blood pressure suddenly increases and causes headache, antihypertensive drugs can be used to adjust the blood pressure, such as amlodipine benzenesulfonate, nifedipine controlled-release tablets and so on. 3. Intracranial space-occupying lesions: for example, intracranial tumors causing headache is mainly treated by surgery. For cerebral hemorrhage, mannitol and furosemide should be given to reduce pressure by dehydration and diuresis. In severe cases, craniotomy and debridement surgery should be performed. Headache recurrence or aggravation should be timely consultation, under the guidance of the physician, after the cause is clear to give targeted treatment, do not blindly use their own medication to avoid adverse consequences.