Redness of the lips and mouth is the initial manifestation of oropharyngeal changes caused by cutaneous mucosal lymph node syndrome. Cutaneous mucosal lymph node syndrome, also known as Kawasaki disease (Kawasakisyndrome), is an acute systemic vasculitis with predominant onset in infants and children. The disease was first reported as cutaneous mucosal lymph node syndrome after cases with characteristic manifestations such as persistent fever, rash, and lymphadenopathy, after which it was then found that Kawasaki disease was not a benign disease and that many children died due to complications of cardiovascular disease; in fact, Kawasaki disease has become one of the two major factors causing acquired cardiovascular disease in children, and in many places its risk is even greater than rheumatic fever in many places. What are the tests for Kawasaki disease, a disease associated with redness of the mouth and lips? In the acute phase, the total number of white blood cells and the percentage of granulocytes increase, the nucleus shifts to the left, mild anemia is seen in more than half of the patients, the blood sedimentation increases significantly, up to 100 mm in the first hour, the serum protein folk swimming shows elevated globulin, especially α2 globulin increases significantly, albumin decreases, IgG, IgA, IgA increases, platelets start to increase in the second week, the blood is in a hypercoagulable state. The blood is hypercoagulable, anti-streptococcal hemolysin O titer is normal, rheumatoid factor and antinuclear body are negative, C-reactive protein is elevated, serum complement is normal or slightly elevated, leukocytosis and/or proteinuria can be seen in the urine sediment, and various changes can be seen in the ECG, with ST-segment and T-wave abnormalities, but also P-R, Q-R interval prolongation, abnormal Q waves and rhythm disturbances. In half of the cases, various cardiovascular lesions such as pericardial effusion, left ventricular enlargement, mitral valve insufficiency and coronary artery dilatation or aneurysm formation can be detected. Slightly high serum bilirubin or glutamine may be seen, with negative results for bacterial culture and viral isolation.