1. How to adjust the dose of aspirin? High-dose aspirin of 30 -50 mg per kg body weight per day is required early in Kawasaki disease to counteract the inflammatory response. Forty-eight hours after temperature normalization, the dose is changed to a low-dose aspirin of 3C5 mg per kg of body weight per day to prevent intracoronary thrombosis. The course of low-dose aspirin is 3-6 months, or until the dilated coronary arteries return to normal. Children with residual permanent coronary artery lesions need to take low-dose aspirin for a long time depending on the coronary artery lesions. 2.When do I need to switch to other drugs to replace aspirin? (1) When high-dose aspirin is used for anti-inflammatory treatment, if serious liver impairment or allergic reaction occurs, consider switching to flurbiprofen at a dose of 3-5 mg per kg of body weight per day in 3 divided doses. (2) Clopidogrel: It is also an antiplatelet drug with stronger effect than aspirin, and is used in cases where intensive antiplatelet therapy is required, either as a substitute for aspirin or in combination with aspirin. The dose is 1 mg per kg of body weight in a single dose. It may increase bleeding tendency when combined with aspirin. 3.When do I need to take additional Pansentine? How to calculate the dose and how long do I need to take it? Pansentin is a non-nitrate coronary artery dilator, which has the effect of dilating coronary vessels, promoting the formation of collateral circulation and mild anticoagulation and antiviral. It is now mostly used in loading tests of myocardial perfusion to evaluate the degree of myocardial ischemia. In Kawasaki disease, pansentine is thought to enhance the antiplatelet effect of aspirin and is generally used in combination with aspirin, but should not be used alone. The pediatric dose of Pansentine is 2-5 mg per kg body weight per day in 3 divided doses. It should be noted that when combined with severe coronary artery stenosis, Pansentine may cause coronary artery theft and induce angina pectoris. 4.What are the possible adverse effects of long-term aspirin use? Although it is very rare for children with Kawasaki disease to develop Reye’s syndrome after applying high-dose aspirin, doctors need to keep an eye out and be alert during the influenza and chickenpox epidemic seasons. Foreign scholars recommend that children with long-term low-dose aspirin use should receive an annual influenza virus vaccine to prevent influenza. The safety of varicella vaccination is unclear, and vaccine manufacturers recommend not taking aspirin within 6 weeks of vaccination. Clinicians need to weigh the adverse effects of continuing to take small doses of aspirin after vaccination against the risk of developing chickenpox without vaccination. Switching to another antiplatelet drug, such as clopidogrel, as an alternative to aspirin may also be considered. One of the more common adverse effects of aspirin is irritation of the gastric mucosa, and some children may experience stomach discomfort or pain after taking it. Aspirin enteric tablets allow the drug to disintegrate and be absorbed in the intestine, reducing the irritation of the gastric mucosa. Taking it after a meal (which should be at least 1 hour apart from eating) is also helpful in reducing gastric irritation. Other adverse reactions to aspirin include allergic rash, induced bronchial asthma, liver function impairment, and bleeding tendency, which need to be noted.