In recent years, many parents rush to bring their children to the hospital to say that the child high fever 4-5 days, the drip also continued not to recede, red eyes, lips chapped, more than crying, not thinking, in the end, what is going on? Zhengzhou University Third Affiliated Hospital Cardiac Center Li Yan, chief physician, said that such a child to be alert to the possibility of Kawasaki disease. She said, Kawasaki disease, also known as cutaneous mucocutaneous lymph node syndrome, was first reported in 1967 by Dr. Kawasaki Tomisaku, Japan, and named after him. This disease infants and children can develop, but 80 ~ 85% of patients within 5 years of age, preferred in 6 to 18 months of infants, more boys, men: women for 1.3 ~ 1.5:1, no obvious seasonal, Asian people with a higher incidence rate. In recent years, the incidence of Kawasaki disease in China is gradually increasing trend, its etiology is unknown, mostly manifested as unexplained fever, lasting 5 days or more, antibiotic treatment is ineffective; bilateral conjunctival congestion; oral and pharyngeal mucous membranes are diffusely congested, lips are red and cracked and poplar tongue; the early onset of the hard swelling of the hands and feet and palmar-plantar redness, as well as the recovery phase of the end of the fingers and toes appeared membranous desquamation; the trunk of the polypoidal erythema; the non-septic swelling of cervical lymph nodes, its diameter, the diameter of the cervical lymph node. Septic swelling of the cervical lymph nodes with a diameter of 1.5 cm or more. Coronary artery damage occurs in about 15% to 20% of children with this disease, and in severe cases, coronary artery aneurysms can occur, leading to myocardial infarction and aneurysm rupture. A small number of children with severe coronary aneurysms can be delayed for several years, leaving coronary artery stenosis, angina pectoris, cardiac insufficiency, ischemic heart disease, myocardial infarction can be life-threatening. Kawasaki disease may also be complicated by gallbladder effusion, arthritis or arthralgia, aseptic cerebrospinal meningitis, facial nerve palsy, hearing loss, acute encephalopathy and neurologic changes such as febrile convulsions. Antibiotics alone are ineffective in the treatment of Kawasaki disease. In the acute stage, intravenous human immunoglobulin, oral aspirin anticoagulation, symptomatic and myocardial nutrition are required. Kawasaki disease is a chronic disease, it is recommended to follow up regularly after discharge from the hospital. Children without coronary artery lesions should undergo a comprehensive examination at 1, 3, 6 months and 1~2 years after discharge from the hospital. Children who have developed coronary artery changes are required to review the cardiac ultrasound and electrocardiogram once in 1-3 months in addition to the general examination, and then once every six months after the coronary arteries have returned to normal, and then once every three consecutive times after the coronary arteries are normal, and then once every 3-5 years after the coronary arteries have returned to normal.