1. Why is it difficult to diagnose Kawasaki disease in its early stages? Kawasaki disease is an acute self-limiting vasculitis in childhood, which mainly occurs in infants and young children under the age of 5 years, with a peak incidence around the age of 1 year. The onset of the disease is characterized by persistent fever for more than 5 days, mostly high, and ineffective anti-infective treatment. And may appear various forms of rash, both eyes ball conjunctiva congestion, lips and oral mucosa congestion, cracking, hands and feet erythema, hard swelling, fingers and toes end of the membrane peeling, and cervical lymph node enlargement. Due to the diagnosis of Kawasaki disease to fever for more than 5 days, other accompanying symptoms are not specific, non-synchronous or atypical performance, and children are often accompanied by coughing, runny nose, hoarseness and other respiratory symptoms, early often easy to diagnose respiratory tract infection. 2. What are the symptoms that parents should be vigilant and send the child to the doctor in time? If the child has a fever for more than five days, the trunk or limbs appear rash, red eyes, lips red with chapped, hands and feet erythema, swelling, and later peeling of the ends of the fingers and toes, cervical lymph node enlargement, etc. to consult the doctor in time. If the blood is high, antibiotic treatment is ineffective, the doctor can not determine the diagnosis, you can go to a specialized hospital, the best time to consult the course of the disease within 5 to 7 days, more than 10 days the incidence of cardiovascular complications will greatly increase. 3. What are the possible consequences of delayed treatment as a cold? Kawasaki disease is a systemic vasculitis, the most important complication is the inflammation of the coronary arteries, causing coronary artery dilation or coronary artery aneurysm, which can lead to coronary artery embolism, myocardial ischemia, myocardial infarction, and pose a danger to the child. Children with large coronary artery aneurysms may rupture the aneurysm due to excitement, crying, or strenuous activity, causing sudden death. If children with Kawasaki disease are diagnosed and treated in time within 5-7 days of the onset of the disease, most of them can be cured without sequelae. 4. What are the possible complications of Kawasaki disease besides cardiovascular complications? What should be checked? Since Kawasaki disease is a systemic vasculitis, all systems of the body can be involved and cause corresponding symptoms: Digestive system: 1/3 of the patients have diarrhea, vomiting, abdominal pain, liver function abnormalities, gallbladder fluid and bile duct dilatation, and even jaundice, which should be tested for liver function. Occasionally, a small number of children have abdominal distension, vomiting and other intestinal obstruction or acute abdomen-like manifestations, and need to take abdominal standing plain film to help diagnosis. Respiratory system: the patient is often combined with respiratory tract infections, such as laryngitis, bronchitis, bronchopneumonia, pleural effusion, etc., and chest radiographs are needed to help diagnosis. Central nervous system: children may cry and agitate, or mental depression, or even have convulsions, which is the manifestation of aseptic encephalitis caused by systemic vasculitis. Some patients need to be differentiated from central infections, and need to do cerebrospinal fluid examination, and some patients may need to perform cranial CT or nuclear magnetic examination to exclude other central lesions or complications, such as cerebral infarction or cerebral hemorrhage caused by vasculitis. Musculoskeletal system: some patients may be combined with arthritis and joint pain. Those with severe symptoms need to undergo nuclear magnetic resonance examination. Urinary system: some patients can be seen in routine urinalysis, urine leukocytes increased significantly, for the combination of aseptic urethritis, sometimes need to do mid-stage urine culture, and urinary tract infection. Very few patients will develop acute renal insufficiency. Hematologic system: Occasionally, there are patients with hemophagocytic syndrome, which can be life-threatening and requires bone marrow aspiration. For children with the above manifestations, due to the complexity of the condition, it is easy to misdiagnose, parents must cooperate with the doctor, timely examination, timely diagnosis, timely treatment, to prevent the emergence of complications. 5. Within what range of coronary artery dilatation do parents not need to worry too much? Can coronary artery dilatation be restored to normal? At present, most hospitals in China diagnosis of coronary artery dilatation diagnostic criteria adopted by the Japanese Ministry of Health in 1984 to formulate the diagnostic criteria of coronary artery anomalies: <5 years old: coronary artery lumen internal diameter >3mm; ≥5 years old coronary artery lumen internal diameter >4mm; lesions in the area of vascular lumens ≥ neighboring blood vessel lumens 1.5 times the internal diameter or lumens irregularities, obvious abnormality. When the coronary artery is tumor-like expansion is diagnosed as tubular aneurysm: internal diameter <5mm for small coronary artery aneurysm, 5~8mm for medium coronary artery aneurysm, >8mm for giant coronary artery aneurysm. If the coronary artery is mildly dilated, i.e., within 5mm of non-tumor-like dilatation most of them can return to normal, small and medium coronary artery aneurysm most of the patients can return to normal, but the recovery is slower, the recovery of large coronary artery aneurysm takes several years, and anticoagulant must be taken for a long time to avoid vascular embolism, which can cause ischemic heart disease. Huge coronary artery aneurysm is often difficult to return to normal, and prone to thrombosis, coronary artery stenosis, and may even rupture the coronary artery aneurysm, the prognosis is poorer, need long-term anticoagulant treatment, and if necessary, need surgical treatment.