Kawasaki disease (KD), once known as mucocutaneous lymphnode syndrome (MCLS), was first reported by Tomisaku Kawasaki in Japan in 1967. It is an acute febrile rash disease with immune-mediated systemic vasculitis as the main lesion, most commonly seen in infants and young children. Because of the serious cardiovascular lesions that can occur in this disease, this disease has replaced rheumatic fever as one of the main causes of pediatric acquired heart disease in China. Diagnostic points 1, clinical diagnosis based on (1) the main symptoms and signs: ① fever lasted 5 days or more than 5 days, was arrested fever or flaccid fever, antibiotic treatment is ineffective; ② bilateral conjunctiva transient congestion, but no exudate; ③ mouth and lips bright red, dry, cracked, bleeding, diffuse congestion of the oral mucosa, with a poplar tongue; ④ onset of the initial hard swelling of the hands and feet, palms and metatarsals, red, the second week of the beginning of the end of the toes and toes of the membranous desquamation; ⑤ trunk Polymorphic erythema without crusts and herpes; ⑥ Non-suppurative cervical lymph node enlargement. The diagnosis can be made if the above five conditions are present. If echocardiography or coronary angiography confirms the presence of coronary aneurysm, the diagnosis can also be made with the above 4 conditions. (2) Cardiovascular system: coronary arteritis, coronary artery aneurysm, cardiocytitis, heart failure and cardiogenic shock can occur. (3) Other accompanying symptoms: urethritis, arthritis, mild jaundice, aseptic meningitis and pneumonia may occur. (1) Blood test: leukocyte increase, left shift of nucleus, thrombocytosis (from the second week), rapid blood sedimentation, normal anti-O, negative rheumatoid factor and antinuclear antibody, increased immunoglobulin and circulating immunocomplexes, bilirubin, gammaglobulin, etc. (2) ECG: No characteristic features. (2) Electrocardiogram There are no characteristic changes. When there is pericarditis, there may be extensive ST-segment elevation and low voltage; when there is myocardial infarction, there is obvious ST-segment elevation, T-wave inversion and abnormal Q-wave. (3) Echocardiography: pericardial effusion in acute stage; coronary artery dilatation and thrombosis in coronary artery aneurysm. (4) Coronary angiography can be performed if there is myocardial ischemia on electrocardiogram and multiple coronary artery aneurysms on echocardiogram, so as to understand the degree of coronary artery lesions and to carry out appropriate treatment. Differential diagnosis 1, scarlet fever, mostly seen in children aged 3~7 years old, rash 1~2 days after the disease, dense rash, skin congestion between the rashes, there are perioral white circles, because of hemolytic streptococcal infection, antibiotic treatment is effective. 2, juvenile rheumatoid arthritis (systemic) fever period is relatively long, can last several weeks to months, knee, wrist, elbow, shoulder, ankle joints are also often violated, some of the children rheumatoid factor positive. 3, exudative erythema rash with vesicles, blisters and crusts, eyes, lips with purulent secretions and pseudomembrane formation; and Kawasaki disease children eyes, lips without purulent secretions and pseudomembrane formation; rash without blisters and crusts. 4, should also be differentiated from sepsis and other infectious diseases. Therapeutic focus 1, aspirin: 30~100mg/kg per day orally, 3 days after the fever subsides, gradually reduce the amount, about 2 weeks or so to 3~5mg/kg per day, maintain 6~8 weeks. If there are coronary artery lesions, the medication should be extended until the coronary arteries return to normal. 2, high-dose gammaglobulin (IVIG): early (within 10 days of disease) application can significantly reduce the occurrence of coronary artery lesions. Usage: a single dose of 2g/kg, in 8 ~ 12 h or so intravenous slow input, should be combined with the application of aspirin, the dose and duration of treatment as above. If the effect of IVIG treatment is not good and fever still occurs, IVIG 1~2g/kg can be added and injected intravenously at one time. 3.Corticosteroid: Because it can promote thrombosis, it is not used under normal circumstances. If IVIG treatment is ineffective and the condition is difficult to control, it can be considered to be combined with aspirin and dipyridamole. Commonly used prednisone 1~2mg/kg per day orally, after the fever subsides, gradually reduce the amount.