1. What are the drugs of choice for the treatment of Kawasaki disease? Kawasaki disease is a systemic vasculitis, and the main treatment is to control vascular inflammation and prevent platelet aggregation, and to prevent coronary artery aneurysm formation and vascular embolism. Intravenous propecia (IVIG) is preferred for intravenous infusion to control inflammation. And use aspirin orally to play the role of anti-inflammatory and anticoagulant. 2. When is the best time to infuse Gammaglobulin? How to calculate the infusion dose? The optimal treatment period of intravenous gammaglobulin is 5-7 days of the disease, preferably not more than 10 days, <5< span="">days of use, the effect is often bad, will increase the dosage of gammaglobulin, >10 days of use, more than the optimal time for the prevention of coronary artery dilatation, the child is prone to sequelae. Use the dose of 2g/kg, one day infusion, or 1g/kg for 2 days. 3. Some children are not sensitive to gammaglobulin, what is the next step in treatment? (Will the hormone encourage coronary tumor production?) In most children, the fever subsides 48 hours after the use of IV Gammaglobulin, inflammatory markers decrease, and the disease is under control. However, there are a few patients who still don’t get rid of fever 36~48 hours after using IV Procalcitonin, they are not sensitive to Procalcitonin treatment, they need to use it again, if the condition can’t be controlled by using it again, hormone treatment can be added, hormone treatment must pay attention to anticoagulation, especially for the children who have difficulty in taking the medication, because hormone has procoagulant side effects, if your child has difficulty in taking the medication, he or she must tell the physician to take other anticoagulant measures, so as to avoid the occurrence of blood clots and other side effects. If your child has difficulty in taking the medicine, you must tell your physician and take other anticoagulation measures to avoid side effects such as blood clots. 4.What should I do if I need to adjust my aspirin dosage or change my medication? The dosage of aspirin is generally used in the acute stage with medium dose, to play the effect of anti-inflammatory and anticoagulant, which is 30~50mg/kg per day, divided into 3~4 times, and then changed to anticoagulant, i.e., small dosage, which is 3~5mg/kg per day, divided into 2~3 times after the condition is controlled and the inflammatory indexes are normalized. If the child has a giant coronary artery aneurysm (>8mm), warfarin anticoagulant therapy is required. Patients taking warfarin must adjust the dose according to the coagulation function under the monitoring of the doctor. 5. When do I need to take Pansentin? How to calculate the dosage? Pansentin, also known as Dipyridamole, has the effect of anti-platelet coagulation. In the subacute and recovery period of Kawasaki patients, some patients’ platelets will be significantly elevated, even up to 450~1500109, taking Pansentin can assist aspirin to co-coagulate and prevent the occurrence of myocardial ischemia. The dosage is 3~5mg/kg per day, divided into 2~3 times. 6. Are there any side effects of taking aspirin for a long time? How to monitor? The main side effects of aspirin are gastrointestinal discomfort, rare gastrointestinal bleeding and perforation. Be careful not to take the medicine on an empty stomach and observe your child’s bowel movements, such as black stools and bloody stools, and promptly go to the hospital for examination. Secondly, due to the inhibitory effect of aspirin on platelets, taking aspirin children may increase the risk of bleeding, a small number of children can be observed petechiae-like rash on the lower legs, parents should pay attention to watch the child during the medication, try to avoid collision or fall. Children who bleed more than once should be taken to the hospital promptly. In addition, a small number of children may have allergic reactions, including rash, urticaria, edema, pruritus, asthma, etc. Need to switch to other drugs. Rarely, there is transient liver damage with elevated liver aminotransferases, and liver function should be monitored regularly. 7. When do I need intervention and bypass surgery? Children with Kawasaki disease need to go to the hospital for regular follow-up. For coronary artery aneurysms ≥6mm, in addition to antiplatelet aggregation and anticoagulation therapy, cardiograms and electrocardiograms should be performed once every 6 months, and exercise stress tests should be performed once a year to monitor the factors that cause atherosclerosis. If the examination suggests that there is myocardial ischemia, coronary angiography should be performed. If the angiography result suggests that there is a significant narrowing of the coronary artery, intervention or bypass surgery is needed. 8. Does the child need to take medication for life? What are the criteria for stopping the medication? Children with Kawasaki disease without coronary artery lesions need to take medication for 6-8 weeks, and those with coronary artery lesions need to take medication until the lesions return to normal and there is no sign of myocardial ischemia. Those who have coronary artery lesions, such as giant coronary artery aneurysms, that are severe and difficult to normalize often need to take medication for the rest of their lives.