If a patient wakes up with a headache while sleeping, the patient should immediately consult a hospital for symptomatic treatment according to the cause.1. Consider that the headache may be caused by subarachnoid hemorrhage or cerebral hemorrhage, which can be done by head CT to quickly clarify. If it is caused by cerebral hemorrhage, the patient should be immediately bedridden and given dehydration and cranial pressure lowering treatment to prevent continued bleeding, strictly control blood pressure, maintain the patient’s vital signs stable, and if the bleeding is large, surgical treatment should be performed. 2. If the patient wakes up with a headache caused by primary headache, such as migraine, neuropathic headache, myotonic headache, cluster headache attack, symptomatic oral pain medication should be taken to relieve the pain. Patients can be given oral aminoglutethimide tablets, acetaminophen, zolmitriptan and other drugs to relieve.