The occurrence of depression is mainly related to various factors such as genetic factors, mental stress and major events. Most patients with moderate depression, after long-term active treatment, can return to their pre-onset state and return to normal family and social life. Clinical treatment for moderate depression is based on psychotherapy, medication and physical therapy: 1. Psychotherapy: patients with moderate depression can try psychotherapy first, and after psychotherapy is ineffective, it can be combined with medication. It is recommended that patients with more serious symptoms should go to the psychiatric psychology department of the hospital as soon as possible to receive regular psychological guidance treatment, and through timely detoxification of psychological stress and bad mood, it can promote the recovery of moderate depression. In addition, depressed patients should also learn to self-regulate, try to expand their social circle, appropriately carry out their favorite sports, maintain a good diet and living habits, and promote the recovery of the disease as soon as possible by relieving bad moods; 2, medication: medication is the main way to treat moderate depression, and there are many drugs commonly used in clinical practice, mainly including sertraline, paroxetine and other selective 5-hydroxytryptamine reuptake inhibitors The above drugs can inhibit the reuptake of epinephrine and dopamine, which can regulate the nerves and relieve moderate depression; 3. The excitability of neurons can be regulated to achieve the purpose of relieving moderate depression.