Can gallbladder stones cause heart disease and what is meant by gallbladder heart syndrome? Gallbladder stones and coronary heart disease are both common in middle-aged and elderly people, and both are often seen in the same patient. Therefore, it was previously thought that gallbladder stone disease could cause heart disease. However, in recent years, through a series of animal experiments and clinical observations, it has not been found that gallbladder stones can cause heart disease, but that when the two diseases are present together, biliary colic attacks can cause the appearance of coronary heart disease symptoms, which is clinically known as biliary heart syndrome. The mechanism that causes biliary heart syndrome is due to the fact that the nerves innervating the biliary tract and the heart, which partially cross at the spinal cord area, can be reflexed through the nerves when gallbladder disease strikes. The reflexes cause constriction of the diseased coronary arteries and reduced blood flow, which leads to angina pectoris, arrhythmias and ECG abnormalities. In this case, the treatment is often unsatisfactory if only coronary artery-dilating drugs are used. In particular, the arrhythmia of biliary heart syndrome, the application of general anti-arrhythmic drugs is not effective, but the use of those drugs to reduce biliary angina such as atropine, dulcolax, etc. but effective.