The severity of peripheral neuropathy is related to the condition and its rate of progression, e.g., patients with primary trigeminal neuralgia often have a better prognosis when treated aggressively, and Guillain-Barré syndrome may cause severe sequelae and be more severe. Peripheral neuropathies may be related to factors such as nutrient metabolism, inflammation, trauma, tumors, genetics, medications, and toxicity, which can injure peripheral nerves locally or lead to widespread damage. For diabetic peripheral neuropathy, primary trigeminal neuralgia and other peripheral neuropathies, the damage caused is more limited, the disease progresses more slowly, generally less serious, and the symptoms can be significantly relieved after active treatment, with a better prognosis. It may also lead to serious consequences if the patient is not treated in time. For Guillain-Barré syndrome, a peripheral neuropathy, although self-limiting, due to the wide range of lesions and the involvement of many nerves, some of them may leave serious sequelae, and a few of them will die due to respiratory failure, infection, hypotension, etc., which is more serious. If peripheral neuropathy occurs, it is necessary to actively seek medical advice and rational treatment under the guidance of physicians.