Ankylosing spondylitis is a common type of seronegative spondyloarthritis that is difficult to diagnose early and easily misdiagnosed, so it is not as often seen as rheumatoid arthritis, but the dangers of the disease cannot be ignored. It has been reported that the disability rate for ankylosing spondylitis can be as high as 30%. There is still too little awareness of ankylosing spondylitis among individual patients and society as a whole, and not enough attention is paid to it. By the time patients become aware of the disease, it is often in the middle to late stages and the damage caused is usually irreversible. Ankylosing spondylitis is a chronic progressive rheumatic disease that is primarily a chronic inflammation of the spine itself and its accessory tissues, but can also involve peripheral joints, internal organs and other tissues. The current prevalence of the disease in China is about 0.26%, with a male prevalence and a male to female ratio of about 2-3:1. The age of onset is often between 10-40 years, with a peak at 15-35 years. Most patients with ankylosing spondylitis have inflammatory lower back pain: the onset is insidious, back pain is often more pronounced at night, in the morning or after prolonged sitting or standing, and can be reduced after activity or with non-steroidal anti-inflammatory drugs, and when the back pain is severe, it can affect sleep or even difficulty turning over. Therefore, if you have chronic inflammatory low back pain, do not take it lightly, you should find a rheumatologist as soon as possible to rule out the possibility of ankylosing spondylitis. Although ankylosing spondylitis is a genetic disease, its pathogenesis is not yet fully understood, and there can be significant differences between individuals in terms of first symptoms, location of involvement, severity of symptoms and outcome. There can also be ophthalmia, chronic diarrhea and even skin mucosal or visceral lesions. Therefore, early diagnosis of the disease is difficult, and it is often missed or misdiagnosed as lumbar disc herniation, rheumatoid arthritis, or lumbar strain. About 30% of patients with ankylosing spondylitis are chronically misdiagnosed and mismanaged, with the average misdiagnosis lasting as long as 6 years. He cited the example of a 20-year-old boy from Heyuan, Xiao Yu, who accidentally hit his right foot on a rock in the fourth grade, and the swelling and pain in his heel has not subsided, which was misdiagnosed locally as osteochondritis. Although Xiao Yu was diagnosed in a major hospital in Guangzhou 2 years ago, after systematic systemic drug and even biologic treatment, his condition was not only not relieved, but his left heel also became severely swollen and painful a year ago, until 3 months ago when he was referred by a patient to the Second People’s Hospital of Guangdong Province to receive ultrasound-guided local injection of bilateral Achilles tendon ends, and with It was not until 3 months ago that he was referred by a patient to the Guangdong Second People’s Hospital to receive ultrasound-guided local injections of the bilateral Achilles tendon ends and systemic medication that his condition was gradually relieved. The misdiagnosis and mistreatment not only made Xiao Yu’s body and mind suffer for many years, but also brought a heavy economic burden to the family. Early treatment is the key to preventing disability. Ankylosing spondylitis cannot be completely cured, but can only be cured by eliminating as much active inflammation as possible, preventing further bone erosion and ligamentous ossification, maintaining spine and joint function, and preventing the emergence or aggravation of disability. Since there are no drugs or treatments that can reverse chronic bony lesions of the spine or peripheral joints that have already developed in patients, early diagnosis and treatment are essential to prevent disability in patients with ankylosing spondylitis. A growing number of studies have shown that patients with sacroiliac joint x-rays negative for medial spondyloarthritis who receive aggressive anti-inflammatory therapy at an early stage can expect to not only delay or even halt the progression to ankylosing spondylitis, but also have the potential for prolonged drug-free remission. Prevention: Exercise More Avoid Trauma and Infection If someone in the family has the disease, is it likely that a relative will also get it? However, genetics is not the only factor that leads to the development of ankylosing spondylitis. Environmental factors such as infection, trauma, and stress may also trigger the development of ankylosing spondylitis. Therefore, young people, especially those with a clear family history of the disease, should try to avoid gastrointestinal and urinary tract infections and trauma in their lives to avoid triggering the disease. For patients who have been diagnosed, it is important to exercise to increase or maintain the mobility and flexibility of the spine and joints, reduce pain, increase muscle strength and endurance, prevent osteoporosis and muscle atrophy, and help prevent disability.