One of the typical clinical manifestations of ankylosing spondylitis (AS) is inflammatory low back pain, characterized by insidious onset, nocturnal pain that decreases with activity but worsens with rest, and effective anti-inflammatory analgesics. Nowadays, more and more patients, especially young patients, are becoming more aware of AS, but many patients still do not have a comprehensive understanding and focus only on the changes of low back pain during diagnosis and treatment. In fact, the essence of AS is a systemic inflammatory disease, and in the early stage of the disease, pain is a manifestation of inflammation, and when the inflammation is controlled, the pain will be reduced to gradually disappear in most patients, but it is not always the case, and in some patients, even though the pain disappears after treatment, blood tests still show obvious inflammatory reactions. treatment. The persistence of inflammation is the root cause of ongoing damage to the body, so in addition to self-perception, it is important to respect science and to regularly visit the rheumatology department of the hospital for monitoring of inflammation indicators, which helps doctors to adjust treatment in a timely manner. On the other hand, for patients in the middle and late stages, the inflammatory response is gradually quiescent, but the pain is still obvious, and this pain is a manifestation of chronic bone and joint and tendon and nerve injuries, rather than ineffective treatment, and the therapeutic drugs should be converted accordingly to achieve satisfactory results. AS not only involves the spine including the lumbar, thoracic and cervical spine, gradually causing spinal ankylosis, ligamentous bones, osteoporosis and even compression fractures, but also affects the limb belt joints such as the double hip and shoulder joints; peripheral joints such as the knee, ankle and toe joints, and tendon attachment points such as the pelvis, heel and patellar ligaments, causing joint effusion and soft tissue swelling, and gradually causing various erosion and destruction after untimely treatment. In addition, AS also causes damage to internal organs and various organs of the body, for example, aortic root dilatation, valve expansion regurgitation and even prolapse, and the early stage of the lesion delays the diagnosis and treatment because the patient has no symptoms, and in the late stage, open heart valve replacement surgery has to be performed, but in the case of systemic inflammation is not fully controlled, after hastily and blindly performing surgery, perivalvular leakage is often difficult to avoid, and the surgery ends in failure, and reoperation gives the patient The surgery ends in failure and reoperation causes great physical damage and monetary loss to the patient. Eye injuries manifest as uveitis, vitreous inflammation, retinitis, and even total ophthalmia, where patients suffer from eye pain, redness, blurred vision, and even sudden blindness, requiring strong treatment as soon as possible to avoid lifelong regrets. Some patients with spondyloarthritis can be accompanied by psoriasis (skin disease), inflammatory bowel disease (such as Crohn’s disease, ulcerative colitis), etc., and have long been misdiagnosed as common dermatitis or enteritis. In addition, many patients with spondyloarthropathies suffer from depression, anxiety, sleep disorders, etc. It is not uncommon for young patients to work with the disease, and the feeling of difficulty in coping with the pressure of work is always present, and even the salary is significantly affected. The social life and recreational activities of many patients are significantly reduced. In the middle and late stages, patients have limited movement of the lumbar and cervical spine, significantly reduced visual field, difficulties in toileting and exercise, and poor quality of life. In order to avoid various damages in the middle and late stages of the disease, early diagnosis and rapid and complete control of inflammation are necessary to achieve the therapeutic goals of sustained improvement of symptoms, improvement of the functional level of the body, and eventual restoration of work capacity and improvement of quality of life.