Gallbladder stones are one of the very common clinical diseases. In general, gallbladder stones can block the gallbladder duct and irritate the gallbladder mucosa, causing acute or chronic inflammation of the gallbladder. They are manifested as a significant thickening of the gallbladder wall and an increase in the size of the gallbladder. Patients may experience clinical symptoms such as pain in the right upper abdomen, nausea and vomiting, accompanied by radiating pain in the back of the right shoulder. Once severe suppuration or gangrene of the gallbladder occurs, patients often need longer anti-infection treatment, and the treatment effect is often poor. So how should gallbladder stones be treated and when is the best time to treat them, let’s all learn together below. In general, if stones in the gallbladder do not block the bile duct or cause acute infection of the gallbladder, patients often do not have obvious symptoms of abdominal pain, and most patients are not aware of their combined gallbladder stones if they are not examined by routine physical examinations or other diseases. For asymptomatic gallbladder stones, generally the adhesions around the gallbladder are relatively loose and the anatomical structure of the gallbladder triangle is relatively clear, so this is the best time to remove the gallbladder if it is performed. Because the operation time is shorter, the intraoperative view is clear, the possibility of bile duct and blood vessel damage is extremely low, no abdominal drainage tube needs to be placed during the operation, and the recovery of the patient after the operation is faster. Therefore, this is the best time to operate. However, the majority of patients with gallbladder stones tend to ignore their condition because they do not have obvious abdominal pain symptoms, making it difficult for them to receive surgery. Only after the recurrent inflammation of gallbladder stones do patients pay enough attention to consider surgery, which often misses the best time for treatment and even develops related complications.