Evidence related to nutritional metabolic deficiency disease lesions such as a history of malnutrition with niacin vitamin B1 and folic acid deficiency, signs and symptoms of nutritional metabolic deficiency leading to corresponding functional abnormalities, these can be used as diagnostic conditions for mental disorders associated with nutritional metabolic diseases. The following diseases are also diseases that can cause nutritional metabolic deficiency: 1, nutritional deficiency neuropathy Dystrophic polyneuropathy (dystrophic polyneuropathy) is a common type of polyneuropathy, which is caused by nutritional deficiency or metabolic disorders and is characterized by symmetric sensory deficits in the distal extremities, lower motor neuron paresis and/or autonomic deficits. 2. Folic acid deficiency neuropathy Folic acid deficiency is a clinical syndrome characterized by megaloblastic anemia caused by insufficient intake or malabsorption of folic acid. Folic acid (folic acid) is a fat-soluble vitamin that is abundant in vegetables, yeast, liver, kidney, dairy meat and other foods, but is easily destroyed after cooking. Folic acid is an anti-anemia factor. Deficiency in humans can cause a phenomenon similar to pernicious anemia. When folic acid deficiency, DNA synthesis is impaired, thus causing lesions in the rapidly dividing hematopoietic system and gastric mucosa, which can be complicated by neurological damage. 3, niacin deficiency neuropathy Niacin usually refers to niacin (Nicotinic acid, Nicotinic acid), nicotinamide (Nicotinamide) and other biologically active pyridine derivatives. Niacin deficiency disease is also known as nicotinic acid deficiency, also known as pellagra (mange) and Pellagra disease, niacin deficiency was found to be the cause of the disease in 1937. The human organism can synthesize endogenous niacin, but exogenous intake is necessary to avoid niacin deficiency. The occurrence of this disease is related to the reduced intake and absorption of niacin, niacinamide, tryptophan and metabolic disorders. It is a chronic wasting disease, with dermatitis, dementia and diarrhea as the main clinical symptoms. 4, pediatric folic acid deficiency disease folic acid (folic acid) is a water-soluble B vitamins, due to folic acid and birth defects, cardiovascular disease, such as the relationship between research gradually, it has become an extremely important micronutrient. In the clinical neural tube malformation and megaloblastic anemia caused by folic acid deficiency is not uncommon in the rural areas of Northwest, North China and Southwest China, and needs to be strengthened to prevent and treat. 5, pediatric niacin deficiency disease niacin deficiency disease (nicotinic acid deficiency), also known as mange, or Beyrago disease (pellagra, the Italian translation, meaning rough skin). It is a disease with rash, digestive and neurological manifestations due to the lack of niacin (commonly known as vitamin P-P) or niacinamide in the body. In our ancient times, it was called millet mange. The clinical manifestations of the disease were described in detail as early as the eighteenth century, but it was not until 1917 that Goldberger confirmed that the disease was related to dietary factors. 1937 saw significant results in the treatment of human pellagra with niacin, and in 1945 it was discovered that treatment with tryptophan had the same effect. Niacin and nicotinamide form a system of coenzymes in the body that are required for the cellular respiratory mechanism. Niacin is a water-soluble vitamin that is both heat and base resistant, and is the most stable of all vitamins.