Macrosplenomegaly is primarily a surgical removal of the spleen. Removal of the spleen has the advantage of correcting the harmful effects of splenomegaly, but this method also has shortcomings. Total spleen removal will alter the patient’s immune function, with loss of spleen filtration, decreased IgM, reduced levels of regulatory and modulating hormones, disturbances in the T-lymphocyte system, and a significant decrease in the number of peripheral blood lymphocytes as well as the lymphocyte conversion rate, leading to a significant increase in the chance of outbreaks of infection Surgical trauma is high and costly. There are also poor liver function, ascites, low protein, vomiting blood and other conditions that do not have surgical conditions. In addition to the need to cooperate with the conservative Chinese medicine soup treatment, there is no special medicine for the condition to relieve, just need to control the deterioration of the disease, inhibit the spread of the virus and many other conditions, so it is better to try to be treated as early as possible. The causes of splenomegaly are multifaceted, such as infection, stasis of blood, hyperplasia, etc., and need to be treated for various diseases of various nature, so that the possibility of cure is greater. Preventive measures for giant spleen: 1, usually to develop good habits, not picky, balanced nutrition, maintain hygiene and prevent infection. 2, patients should eat more vegetables and fruits to make up enough vitamins and fiber to help digestive function. 3, a light diet, to low fat, low sugar (too much sugar into the body easily converted into fat), avoid irritating, greasy, fried, raw and cold food. 4, to ensure the right amount of protein, including vegetable and animal protein, such as chicken, fish, beef, soy products, etc.